In that regard, several studies have focused on identifying the signaling pathways indicating the onset of DKD as well as testing new potential biomarkers to achieve the earlier detection of diabetic kidney disease such as NETosis, a novel form of neutrophil-related cell death, and Neutrophil Gelatinase-Associated Lipocalin, to name a few [9,10,11]. This evidence concerns the gene MMP2 and diabetic kidney disease.