Furthermore, in an STZ-induced diabetic rat model, the increased production of 20-HETE was associated with the overexpression of fibronectin and transforming growth factor-β1 (TGF-β1) in the kidneys of the experimental rodents [68], where these molecules are proven to be a profibrotic factor in DKD [69]. This evidence concerns the gene FN1 and diabetic kidney disease.