However, the Sadarangani study assessing the effects of PF-04449913 in CML with RNA-seq analysis did not report the extent of SHH, IHH, or DHH expression, so it is not known whether the HH signaling is being activated in a canonical or non-canonical manner in CML cells [61]. The gene discussed is DHH; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.