The scientific rationale behind the targeted interaction of pEV with cancer cells lies in the vast range of surface receptors and glycoproteins, such as platelet P-selectin (CD62p), GPIIb/IIIa, or PECAM-1 (platelet-endothelial cell adhesion molecule-1), present on the surface of pEV [19]. This evidence concerns the gene PECAM1 and cancer.