In the ovarian cancer CAOV-4 cell line, vaginal-isolated Lactococcus lactis exhibits a comprehensive influence including downregulations on TLR-4, miR-21 and miR-200b expression levels, which have been regarded to correlate with ovarian cancer initiation, metastasis, recurrence and the buildup of chemo-resistance [17]. Here, TLR4 is linked to ovarian cancer.