Studies conducted in vivo in a chronic arthritic model (FCA) induced in rats allowed the authors to demonstrate that the administration of NRG loaded-polymeric nanoparticles produces a greater reduction in the severity of arthritis in FCA than those treated with NRG alone The report indicates decreased levels of proinflammatory cytokines (INF-γ, IL-6, and TNF-α) with an increase in IL-10 (anti-inflammatory cytokine), and the attenuation of serum rheumatoid factor (RF-factor) levels and C-reactive protein (CRP) compared to nanoparticles blank and NRG alone. Here, CRP is linked to arthritic joint disease.