Due to its effective trapping via decarboxylation by the aromatic L-amino acid decarboxylase (AADC), [18F]F-DOPA is a clinically established neuroimaging agent, but can also be used for the detection of neuroendocrine tumors such as medullary thyroid carcinoma (MTC). The gene discussed is DDC; the disease is medullary thyroid gland carcinoma.