At 100 and 250 nM, INY-03-041 induced the degradation of all three AKT isoforms in the breast cancer cell line MDA-MB-468, and reduced the levels of the direct AKT substrates—phosphorylated PRAS40 (pPRAS40) and GSK3β (pGSK3β). Here, AKT1 is linked to breast cancer.