IGHE and allergic disease: There are three directions to follow in the management of allergy induced by FQs, as follows: (1) discontinuation of the causative drug, (2) initiation of an alternative regimen (from another class of antibiotics, if possible), and (3) supportive care (e.g., corticosteroid therapy, electrolytes as fluid replacement, albumin substitution, histamine antagonist, anti-IgE antibody, short-acting beta-adrenergic agonist), depending on the severity of the events [270,278].