Once activated, they produce their own inflammatory mediators, including cytokines, prostaglandins (PG), leukotrienes, nitric oxide (•NO), and large amounts of matrix metalloproteinases (MMP)-3, -9, and -13 in a process that leads to synovial inflammation perpetuation and to the cartilage and bone destruction observed in RA [6,7]. Here, MMP3 is linked to rheumatoid arthritis.