Additionally, the inhibition effects of Schiff bases (10–15) and hydrazineylidene derivatives (16 and 17) were determined against some metabolic enzymes including AChE, BChE, hCA I, and hCA II enzymes, which are linked to some global disorders including Alzheimer’s disease (AD), epilepsy, and glaucoma. This evidence concerns the gene ACHE and early-onset autosomal dominant Alzheimer disease.