All the synthesized Schiff bases (10–15) and hydrazineylidene derivatives (16 and 17) displayed in vitro inhibition effects against cytosolic hCA I, which is associated with cerebral and retinal edema, hCA II, which is associated with edema, glaucoma, epilepsy, and mountain sickness, and AChE and BChE, which have been linked with AD for their inhibition efficacy. The gene discussed is ACHE; the disease is Alzheimer disease.