Bank et al. [131] studied 738 patients with IBD, including CD, UC, or both, from a Danish cohort and identified 19 functional polymorphisms in 14 genes associated with response to treatment with anti-TNFα agents (TLR2, TLR4, TLR9, LY96, CD14, MAP3K14, TNFA, TNFRSF1A, TNFAIP3, IL1B, IL1RN, IL6, IL17A, and IFNG) that were implicated in the inflammatory response mediated by NFκB. Here, TNF is linked to inflammatory bowel disease.