In rats with AF64A-induced memory deficits, a blend of Cyperus rotundus and Zingiber officinale extract improved memory and neuronal density while decreasing oxidative stress and AChE levels via up-regulation of pERK1/2, implying combined neuroprotective effects of Cyperus rotundus and Zingiber officinale in dementia [36]. The gene discussed is ACHE; the disease is dementia.