NFE2L2 and vascular dementia: Another study indicated that gastrodin treatment suppressed ferroptosis induction and improved learning ability and memory impairment in rats with vascular dementia and the basis for the neuroprotective effects was suggested as gastrodin-decreased levels of Fe2+ and MDA and elevated GSH content by upregulation of Nrf2 and GPx4 and down-regulated Cox2 and kelch-like ECH-associated protein (Keap1) [65].