This statement is supported by the fact that alteration of the expression of Rab27a and Rab27b proteins, involved in the transport of late endosomal/lysosomal-like compartments to the plasma membrane in the exosomal pathway [26], result in an alteration of the tumor-cell-derived exosomes tumoral effect [68,69,70]. The gene discussed is RAB27B; the disease is neoplasm.