In fact, although, to our knowledge, it was never described a correlation between VEGFR1 decreased expression and consequent IL8 increased expression, the expression of both genes seems to be tightly regulated, with several studies reporting a correlation between VEGF- and IL8-mRNA expression in human breast cancer [64], human non-small-cell lung cancer [65], human malignant astrocytomas [66], or in human head and neck squamous carcinoma cell lines [67]. This evidence concerns the gene CXCL8 and astrocytoma (excluding glioblastoma).