DTB also inhibits the discoidin domain receptors 1 (DDR 1) and 2 (DDR 2), as well as tumor necrosis factor-alpha (TNF-α) and interleukin 6 (IL6), the receptors and inflammatory cytokines that play crucial roles in the progression of RA [8,14,15,16]. This evidence concerns the gene IL6 and rheumatoid arthritis.