Given the role of FOXO3 in the circFGFBP1 expression, we finally demonstrated that FOXO3-activated circFGFBP1 inhibits ECM degradation and NP cell death via the miR-9-5p/BMP2 axis in intervertebral disc degeneration in vivo and in vitro. Here, BMP2 is linked to Intervertebral disk degeneration.