Moreover, propolis revealed its ability to inhibit inflammatory mediators including tumor necrosis factor alpha (TNF-α), inducible nitric oxide synthase (iNOS), cyclooxygenase-1/2 (COX 1⁄2), lipoxygenase (LOX), prostaglandins (PGs), and interleukin 1- β (IL1-β) and other cancer inflammatory mechanisms [26]. The gene discussed is TNF; the disease is cancer.