Several other studies used breast cancer cell lines and prostate cancer cell lines models and demonstrated that propolis could trigger apoptosis through the same mechanism across different cancer cell types, which has been found to be through downregulating PI3K/Akt, p38 MAPK, and ERK1/2 signaling pathways, ER stress, and ROS production and subsequent loss of mitochondrial potential [130,131,132]. Here, MAPK3 is linked to cancer.