Despite promising utilities, there are some pitfalls in FAP-targeted tracers, as non-tumor related uptake of [68Ga]Ga-FAPI-04 and [68Ga]Ga-FAPI-46 by degenerative lesions associated with joints and vertebral bones, muscles, scars, head-and-neck, and mammary glands has been reported [27]. This evidence concerns the gene FAP and neoplasm.