TRPV4 and Headache: The relation between migraine headache and TRPV4 lies in the mechanosensitive activation of dural afferent nociceptors; a mechanical stimulation of TRPV4 followed by sudden changes in intracranial pressure (e.g., coughing, sneezing, standing/sitting, or exercising) increase the sensitivity of meningeal nociceptors and exacerbate migraine headache.