PPS is as efficient as heparin in potentiating the mitogenic activity of acidic fibroblast growth factor aFGF, acidic FGF) on human umbilical vein endothelial cells, it regulates cytokine and inflammatory mediator production [65,66,68] and it is an anti-tumor agent in a number of cancers [76,92,93]. This evidence concerns the gene FGF1 and cancer.