Likewise, ciltacabtagene autoleucel (cilta-cel), which contains two anti-BCMA-targeting single domains was approved in 2022 after a phase Ib/II CARTITUDE-1 trial (NCT03548207) on double refractory MM patients who received four or more prior lines of therapy, including a PI, an IMiD, and an anti-CD38 monoclonal antibody. This evidence concerns the gene CD38 and Miyoshi myopathy.