The osteoprotective effect of AA was detected in receptor activator of nuclear factors κB ligand (RANKL)-induced osteoclastogenesis and in lipopolysaccharide (LPS)-induced osteolysis models [19], while its mitigation effects on nephropathy progression were detected in the kidney in type-2 diabetes mellitus (DM) [1]. This evidence concerns the gene TNFSF11 and diabetes mellitus.