GPX4 and colorectal carcinoma: Furthermore, genome-wide transcriptomic profiling analysis demonstrated that the combined treatment with curcumin and andrographis resulted in the induction of ferroptosis in CRC cells, which is in part mediated by the dual suppression of glutathione peroxidase 4 (GPX-4) and ferroptosis suppressor protein 1 (FSP-1), the major negative regulators of ferroptosis [26,27,28].