At present, most of the classes (angiotensin-converting enzyme (ACE) inhibitors, angiotensin II receptor blockers (ARBs), alpha blockers, calcium channel blockers, and direct vasodilators) used for the management of hypertension are aimed to offset arterial vasoconstriction while only beta blockers are aimed to normalize the heart rate by blocking β1 receptors in the heart. This evidence concerns the gene ACE and Hypertension.