TNFSF10 and thyroid gland papillary carcinoma: Combination treatment with valproic acid and the anticancer agent TRAIL (tumor necrosis factor-related apoptosis-inducing ligand) also synergistically induced apoptotic cell death in TRAIL-resistant papillary thyroid cancer (PTC) cells through caspase activation, as well as cell death (via suppression of Bcl-xL by downregulating NRF2-signaling) [117].