While IAV infection can lead to severe disease phenotypes, such as pneumonia and acute respiratory distress syndrome (ARDS) as well as diarrhea and abdominal pain (usually in children), SCV2 infection additionally can lead to severe endothelial damage, vascular thrombosis with microangiopathies, occlusion of vascular capillaries, and cytokine storm characterized by high levels of IL-6 [12]. This evidence concerns the gene IL6 and acute respiratory distress syndrome.