SETD2 and colorectal cancer: Moreover, overexpression of the PKMT known as SUV39H1 activates migration of breast and colorectal cancer cells [39]; SETD2 trimethylates α-tubulin lys40 to regulate mitosis and cytokinesis [40] and methylates β-actin lys68, participating in its polymerization [41]; EZH2 methylates actin-binding protein talin, a key regulatory molecule in cell migration, disrupting its binding to F-actin, leading to turnover of adhesion structures [42].