While MSMDs were initially recognized for their distinct susceptibility to mycobacteria (particularly non-tuberculous (NTM) and occasionally M. tuberculosis) and Salmonella (predisposing victims to extra-intestinal salmonellosis) [38,39,150,151,152,153,154], they were also subsequently found in patients with otherwise unexplained disseminated TDEF infection, including histoplasmosis (IL12RB1 [153,155,156,157]; IFNGR1 [158]), coccidioidomycosis (IFNGR1 [159] and IL12RB1 [160]), and paracoccidioidomycosis (IL12RB1 [161]). Here, IFNGR1 is linked to histoplasmosis.