The molecularly defined IEI associated with severe or disseminated cryptococcosis strikingly overlap with those that predispose one to infection with TDEF, namely, MSMD [253,254,255], GATA2 [174,176], CD40L deficiency [163,256,257,258,259,260,261,262,263], STAT1 GOF [47,264,265], and DN-STAT3 [266,267]; these IEI have been detailed above. The gene discussed is STAT1; the disease is infection.