IL22 and autoimmune polyendocrine syndrome type 1: Beyond genetic lesions that compromise the production of IL-17/IL-22 or the response to IL-17, CMC can also result from the neutralization of these two cytokines, as shown in autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED, also called Autoimmune polyglandular syndrome type 1 [APS-1]), which is typically due to AR mutations in AIRE, although dominant-negative mutations have also been reported [65,66].