It has also been used successfully for this mycosis in patients without identified IEI [219,220,221], although one case presented modest improvement with IFN-γ, and the identification of a dysregulated Th2 response with the subsequent addition of dupilumab (to block IL-4- and IL-13-mediated Th2 responses) led to resolution [221]. Here, IFNG is linked to fungal infectious disease.