As a matter of fact, critically ill people experiencing severe COVID-19 has been shown to exhibit a significant impairment of classical and loss of non-classical monocytes, as well as a reduced number and dysfunction of dendritic cells (DCs) and NK cells, followed by a decrease in CD4+ and CD8+ T cells that also become more activated [9,10,11]. The gene discussed is CD8A; the disease is COVID-19.