However, it has also been described that, in critical COVID-19 patients, CD4+ T cells may get stuck in a naïve state due to high levels of T-cells dysregulation [42], the observation of low frequencies of less differentiated CD4+ T cell subsets might reflect the continuous functional activation of T cells, leading to the accelerated consumption of naïve T cells through apoptosis or differentiation into specialized subsets, as already described for other viral infections [43]. Here, CD4 is linked to viral infectious disease.