TGFB1 and Hepatic fibrosis: We also reported that several plant extracts, including Agaricus blazei, Casticin, and Schisandrin B, can regulate the transforming growth factor β (TGF-β), which affects the changes of the α-smooth muscle actin (SMA) and collagen 1, consequently altering the severity of the liver fibrosis in infected mice [34,35,36].