This allows downstream phosphorylation of Samd2, Smad3, and Smad4 to regulate the expression of αSMA in the HSCs to change the cell morphology, transform into myofibroblasts [13,14,15], then activate fibrotic collagen 1, collagen 3, fibronectin, and other ECM synthesis [12,16], eventually leading to liver fibrosis. The gene discussed is ACTA1; the disease is Hepatic fibrosis.