Out of the 46 HIV-uninfected individuals, 12 patients (26.1%) received B-cell immunosuppressive drugs along with steroid therapy, 5 patients (10.9%) had cancer and received targeted therapy, 3 patients (6.5%) had AOID caused by anti-IFN-γ AAb, and 1 patient (2.2%) was a solid organ transplant recipient. The gene discussed is IFNG; the disease is cancer.