On the other hand, a lipid derived from Pinellia pedatisecta decreases the mRNA expression of E6 in HR-HPV-positive cervical cancer cell lines such as CaSki and HeLa cells, which was associated with an increase in both messenger RNA (mRNA) and protein levels of p53, Bax, and caspase-3, inducing mitochondrial apoptosis [92]. Here, CASP3 is linked to cervical carcinoma.