In the content of the lactate biosynthesis pathways, over-expression of hexokinase 2 (HK2) and lactate dehydrogenase A (LDHA), the committed steps to regulate magnitude and direction of glucose flux for lactate production, are required for tumor initiation, maintenance, and metastatic cancer spread [31,32]. This evidence concerns the gene HK2 and metastatic malignant neoplasm.