We, therefore, established the in vitro FD-exposed lung carcinoma cell and dietary FD intervention of an FD-exposed LC-implanted mouse model to evaluate (1) the causal effects of dietary FD exposure on lactate metabolic disorders in the TME and LC metastasis and (2) to depict the lactate metabolic effects of dietary FD on the metabolic stress regulator, the mTOR-signaling pathway, and its druggable oncotargets in relation to LC metastasis. This evidence concerns the gene MTOR and Other metabolic disease.