Correspondingly, FD activation of mTOR-signaling pathways was apparent by significantly increased expression of pmTOR (Figure 4a,c) and its two downstream targets of p-S6K1 (Figure 4a,d) and HIF1α (Figure 4a,e) in the FD sham mice compared with the control sham mice. This evidence concerns the gene RPS6KB1 and Fabry disease.