H6PD and neoplasm: In line with the mTORC1-signaling lactate anabolic metabolism, the FD/LCS-activated mTORC1/HIF-1α signaling cascade coincided with increased lung/tumor expression of rate-limiting enzymes for anabolic metabolism such as G6PDH which drives to the pentose phosphate pathway for nucleotide synthesis, ACLY for fatty acid synthesis, and empowers redox potential by increased ratio of NADPH/NADP+ and NADH/NAD+ in paired lung tumors.