Of note, a subset of downregulated genes (tfrc, spry4, gbp1, gbp3, prag1, amigo2, and ptpre) were related to the Rho GTPase pathway; among them, amigo2 has been suggested as a biomarker of poor prognosis in gastric adenocarcinoma [45,46,47]. This evidence concerns the gene SPRY4 and gastric adenocarcinoma.