MAPT and early-onset autosomal dominant Alzheimer disease: In this extensive and interesting analysis, I noticed that the authors presented the effect of melatonin on the modification of amyloid, tau protein, and neurotransmission in the brain in a very limited way; although the authors gently touch on this problem, the changes of which are significant in post-ischemic neurodegeneration [2] and in Alzheimer’s disease [3].