TNF and psychotic disorder: In this direction, several studies have confirmed a central role of the immune system in the SZ etiopathogenesis, showing an increased inflammatory state with production of pro-inflammatory cytokines such as interleukine-6 (IL-6) and Tumor Necrosis Factor-α (TNF-α), of E2 prostaglandin inflammation mediator (PGE2), and with an increased COX activity, resulting in the production of cyclooxigenasae-2, detected in plasma of patients during the first episode of psychosis (FEP) [44].