FGF21 and metabolic dysfunction-associated steatohepatitis: This is the first study to show that improvement in serum FGF21 is sustained with a long-term exercise training in patients exclusively with NASH, extending the findings of previous study by Taniguchi et al. of 27 elderly Japanese men without established NAFLD which found a short-term five-week aerobic exercise program to decrease serum FGF21 [21].