KL and hyperphosphatemia: The in vivo and in vitro effects of sKlotho found in our study are in keeping with other effects attributed to Klotho such as pro-autophagic actions in heart and kidneys [20], renoprotection [59], anti-apoptotic and anti-senescent actions in endothelial cells [60] and reduction in the negative effects of hyperphosphatemia on VC [8,61].