ADIPOQ and obesity due to melanocortin 4 receptor deficiency: In fact, obesity-induced inflammation through several mechanisms, such as hypoxic hypertrophic adipocyte, adipocyte apoptosis [14,15], reduced adiponectin with elevation of leptin [16], mitochondrial dysfunction [17], and metabolic endotoxemia due to intestinal barrier defect [18] leads to atherosclerosis, a major vascular consequence of obesity [19].