In fact, circadian rhythm disruptions are associated with a higher prevalence of hyperphagia, obesity, metabolic syndrome, hyperlipemia, and hyperglycemia, as demonstrated in a study performed in two American and European independent populations by Aguilar-Galarza et al., [25] and insulin-resistance, as proven by Barrea et al. in a 2022 study which investigated 300 women affected by polycystic ovary syndrome [26]. The gene discussed is INS; the disease is obesity due to melanocortin 4 receptor deficiency.