The study by Moleres et al. in 2012 correlated a high GRS score, including the obesity risk allele G in the rs1800795 (−174 G > C) SNP of the IL6 gene, with greater BMI and fat mass at the beginning, as well as with greater BMI and fat mass reduction following the introduction of lifestyle interventions [61]. This evidence concerns the gene IL6 and obesity due to melanocortin 4 receptor deficiency.