LEP and obesity due to melanocortin 4 receptor deficiency: Some of the genetic loci associated with the pathogenesis of obesity are MC4R, BDNF, SH2B1, POMC, LEP, LEPR, NPY, SIM1, NTRK2, and PCSK1 [15,23], as well as CNVs in 11q11 (OR4P4, OR4S2, OR4C6), 1p21.1 (AΜΥ1), 10q11.22 (NPY4R), 10q26.3 (CYP2E1), 16q12.2 (FTO), 16p12.3 (GPRC5b), and 4q25 loci [28].