In the studies performed by Reinehr et al. in 2008 [65] and 2009 [66], a statistically significant lower BMI and BMI-SDS reduction was noted in homozygous CC carriers in rs7566605 SNP of insulin-induced gene 2 (INSIG2; OMIM * 608660) gene during obesity lifestyle management interventions, while the 2009 study highlighted a synergistic effect in reduced BMI change after intervention in combined homozygous carriers of the CC genotype in rs7566605 SNP of INSIG2 and the AA genotype in rs9939609 SNP of FTO. This evidence concerns the gene FTO and obesity due to melanocortin 4 receptor deficiency.