CADM2 and obesity due to melanocortin 4 receptor deficiency: Interestingly, the obesity risk allele in rs13078960 SNP leads to increased expression of CADM2 in multiple areas of the human brain (caudate basal ganglia, putamen basal ganglia, cerebellum, and hypothalamus), providing further support of the association of CADM2 with increased adiposity and its role in energy homeostasis [79,83].