INSIG2 and obesity due to melanocortin 4 receptor deficiency: In the studies performed by Reinehr et al. in 2008 [65] and 2009 [66], a statistically significant lower BMI and BMI-SDS reduction was noted in homozygous CC carriers in rs7566605 SNP of insulin-induced gene 2 (INSIG2; OMIM * 608660) gene during obesity lifestyle management interventions, while the 2009 study highlighted a synergistic effect in reduced BMI change after intervention in combined homozygous carriers of the CC genotype in rs7566605 SNP of INSIG2 and the AA genotype in rs9939609 SNP of FTO.