PPAR gamma presents pleiotropic functions, taking part in a variety of biological processes, including adipogenesis, glucose metabolism, lipid oxidation and storage, control of autophagy, and inflammatory responses, and has therefore been implicated in the pathological state of obesity, type 2 diabetes mellitus, atherosclerosis, cancer, and Familial Partial Lipodystrophy Type 3 [159,162]. The gene discussed is PPARG; the disease is obesity due to melanocortin 4 receptor deficiency.