ADIPOQ and obesity due to melanocortin 4 receptor deficiency: The proinflammatory state of obesity is also characterized by an anti-inflammatory adaptive response, characterized by changes in T-cell subpopulations in the adipose tissue, such as a CD8+ T cell activation, a decrease in Tregs and Th2 cells, and an increase in Th1 and Th17 cells, as well as disruption of the expression of many adipokines, including adiponectin, resistin, and visfatin [39].