Furthermore, when assessing the dopamine receptor D2 (DRD2; OMIM * 126450) gene, Roth et al. showed that homozygous carriers of Τ allele in rs18000497 SNP near the DRD2 gene exhibited decreased BMI-SDS reduction after a one-year outpatient obesity lifestyle intervention program [67]. Here, DRD2 is linked to obesity due to melanocortin 4 receptor deficiency.