MC4R and obesity due to melanocortin 4 receptor deficiency: Scherag et al. studied variations in five (FTO, MC4R, TMEM18, SDCCAG8, TNKS/MSRA) genetic loci and identified an association of the homozygosity for three intronic SNPs (rs10926984, rs12145833, rs2783963) in SDCCAG8 with reduced BMI change in children/adolescents undergoing a one-year multidisciplinary obesity lifestyle intervention, although similar correlations were nοt identified in an adult sample undergoing an hypocaloric diet intervention [69].