Exploring the nutritional interaction with rs17782313 SNP, regular consumption of meals (5 meals including breakfast versus ≤ 4 meals) in adolescence seem to attenuate the obesity risk from the risk alleles in MC4R rs17782313 in both genders and from FTO rs1421085 only in males, possibly because of more favorable postprandial thermogenic and glucose metabolism responses [110,111]. This evidence concerns the gene MC4R and obesity due to melanocortin 4 receptor deficiency.