The association of the rs10733682 and rs3829849 polymorphisms in LMX1B loci with obesity has been established by GWAS both in adult and pediatric populations [27,82] and may be possibly explained by the role of LMX1B in serotonergic and dopaminergic pathways [98,99]. Here, LMX1B is linked to obesity due to melanocortin 4 receptor deficiency.