Another significant finding from the study by Moleres et al. (2012) was the evidence that children with a higher obesity risk GRS score, constituting the obesity risk G allele of rs1801282 SNP in the peroxisome proliferator activated receptor gamma gene (PPARG/PPARγ; OMIM * 601487) alongside SNPs in FTO, MC4R, TMEM18, IL6, and ADIPQ had greater BMI and fat mass at the beginning together with a greater BMI and fat mass reduction after a 3-month lifestyle intervention, whereas children with lower GRS presented a greater improvement in their metabolic profile after intervention [61]. Here, TMEM18 is linked to obesity due to melanocortin 4 receptor deficiency.