GPX4 and Familial prostate cancer: In particular, prostate cancer has been linked to variants TXNRD1 and TXNRD2 [46], colorectal cancer has been linked to variants GPX1, GPX4, SELENOP, SELENOF, and TXNRD1 [47,48,49,50], lung cancer has been linked to variants GPX1, GPX4, and SELENOF [51,52,53] and increased risk of cardiovascular disease has been linked to variants GPX1 and SELENOS [54,55].