In 16 healthy individuals (8 females (22.2 ± 2.6 yrs) and 8 males (22.8 ± 3.5 yrs)), exposure to bright light (>500 lux) in the evening and while asleep significantly increased plasma glucose and insulin levels compared to dim light exposure (<5 lux), implicating glucose intolerance and insulin insensitivity [97]. This evidence concerns the gene INS and Glucose intolerance.