NR1H4 and metabolic dysfunction-associated steatotic liver disease: There are several representative examples of FXR targets relevant to the pathophysiology of NAFLD, including SREBP1c (de novo lipogenesis), PPARα (fatty acid uptake, binding and oxidation), PEPCK (gluconeogenesis and glyceroneogenesis) and NF-κB (e.g., LPS-mediated inflammation) [76].