INS and Glucose intolerance: Evidence in the literature confirms that high-fat diets result in disturbances in glucose metabolism and glucose intolerance [49], thus causing insulin sensitivity, a condition that is probably associated with reduced expression of transcription factors belonging to the nuclear receptor family, such as peroxisome proliferator-activated receptors (PPARs) and their target genes, which regulate glucose homeostasis, lipid metabolism and inflammation [51,52].