These studies also pointed to a possible effect on sensitive protein kinases for the regulation of intracellular energy (active protein kinase—AMPK), thus influencing the intracellular energy balance, and consequently impacting the energy metabolism of the whole organism; this effect could play a protective role against metabolic diseases such as obesity [47], as well as being an important regulator of lipid and glycemic metabolism [48]. Here, WEE1 is linked to obesity due to melanocortin 4 receptor deficiency.