EPO and influenza: In addition, the role of hypercytokinemia/hyperchemokinemia in the pathogenesis of influenza, IL-17 signaling, acute-phase response signaling, the LPS/IL-1-mediated inhibition of RXR function, the unfolded protein response, and tumor microenvironment pathways were also found to be activated, and the erythropoietin signaling pathway was found to be inhibited (Figure 5B).