For the significant establishment of mushroom-based prevention and treatment of diabetes, more research in the clinical field is needed, such as in vivo animal studies, in vitro enzyme inhibition assays (amylase, glucosidase, pancreatic lipase, and DPP4-dipeptidyl peptidase 4), human trials, pilot studies, and prospective and retrospective studies. The gene discussed is DPP4; the disease is diabetes mellitus.