Moreover, cirsilineol is effective in ameliorating TNBS (tri-nitrobenzene sulfonic acid) -induced experimental colitis in mice, possibly because of its novel immunoregulatory activities with selective inhibitor IFN-γ/STAT1/T-bet signaling in the colonic lamina propria CD4 + T-cells particular for Crohn’s disease [88]. This evidence concerns the gene IFNG and Crohn disease.