ACTA1 and cirrhosis of liver: (v) A rat model of carbon tetrachloride-induced liver cirrhosis or common bile duct ligation-induced liver cirrhosis treated daily with metformin (300 mg/kg) caused a decrease in portal pressure and hepatic vascular resistance as well as inhibition of liver fibrosis, profibrosis biomarker alpha-smooth muscle actin (α-SMA), hepatic inflammation, and oxidative and nitrosative stress [43].