MRP2 is overexpressed in many cancers such as the liver, kidney, and small intestine to play a key role in the transport of many drugs such as cisplatin, doxorubicin, epirubicin, etoposide, irinotecan, mitoxantrone, methotrexate, SN-38, and Vinca alkaloids, in addition to endogenous metabolites. The gene discussed is ABCC2; the disease is cancer.