KEAP1 and Alzheimer disease: Two other research results provided new ideas for the treatment of AD with M. Rhizoma: Wang [58] used the Nrf2/Keap1 antioxidant pathway to verify that dauricine could significantly increase the expression level of Nrf2, a key antioxidant factor, and then used the antioxidant effect of dauricine to repair damaged cells using Aβ aggregation as a therapeutic target; the results demonstrated that dauricine could be brain-targeted for the treatment of AD.